Peran Transforming Growth Factor-B1 pada Penyakit Ginjal
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چکیده
منابع مشابه
Transforming Growth Factor-B1, Transforming Growth Factor-B2, and Transforming Growth Factor-B3 Enhance Ovarian Cancer Metastatic Potential by Inducing a Smad3-Dependent Epithelial-to-Mesenchymal Transition
Transforming growth factor-B (TGF-B) is thought to play a role in the pathobiological progression of ovarian cancer because this peptide hormone is overexpressed in cancer tissue, plasma, and peritoneal fluid. In the current study, we investigated the role of the TGF-B/ Smad3 pathway in ovarian cancer metastasis by regulation of an epithelial-to-mesenchymal transition. When cancer cells were cu...
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PIERRE B. SAADEH,1 BABAK J. MEHRARA,2 DOUGLAS S. STEINBRECH,2 MATTHEW E. DUDZIAK,2 JOSHUA A. GREENWALD,2 JONATHAN S. LUCHS,2 JASON A. SPECTOR,2 HIKARU UENO,3 GEORGE K. GITTES,2 AND MICHAEL T. LONGAKER2 1Department of Surgery, University of Connecticut, Farmington, Connecticut 06032; 2Laboratory of Developmental Biology and Repair, Department of Surgery, New York University School of Medicine, N...
متن کاملTransforming growth factor-β
Dna2 was first characterized in yeast as an essential gene encoding a protein with both helicase and endonuclease activities involved in maturation of Okazaki fragments during DNA replication. Dna2 also plays a role in double-strand break (DSB) repair by homolo-gous recombination. The respective contributions of its replication and/or repair functions toward cell viability and resistance to gen...
متن کاملSerial Measurement of Vascular Endothelial Growth Factor and Transforming Growth Factor-b1 in Serum of Patients With Acute Ischemic Stroke
Background and Purpose—Both vascular endothelial growth factor (VEGF) and transforming growth factor-b1 (TGF-b1) are expressed in higher than normal concentrations in the penumbra of patients after ischemic stroke. Because both cytokines are central to the processes of angiogenesis, tissue inflammation, and fibrosis, we performed serial measurements of these cytokines in patients with cerebral ...
متن کاملTransforming Growth Factor-b1 Induces Desmoplasia in an Experimental Model of Human Pancreatic Carcinoma
Proliferation of fibrotic tissue (desmoplasia) is one of the hallmarks of several epithelial tumors including pancreatic adenocarcinoma. This tissue reaction may be deleterious or advantageous to the host or tumor. In a systematic analysis, we identified two growth factors expressed by human pancreatic carcinoma cells that are positively correlated with the ability to induce fibroblast prolifer...
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ژورنال
عنوان ژورنال: Sari Pediatri
سال: 2016
ISSN: 2338-5022,0854-7823
DOI: 10.14238/sp13.1.2011.49-54